가토의 두개골에서 티타늄 반구를 이용한 다양한 onlay bone graft시 골형성 능력
The effect of new bone formation of onlay bone graft using various graft materials with a titanium cap on the rabbit calvarium
박영준, 박홍주, 국민석, 오희균, 유선열, 유민기, 최근호, 장정록, 정승곤, 한만승,
소속 상세정보
박영준 ( Park Young-Jun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
박홍주 ( Park Hong-Ju ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
국민석 ( Kook Min-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
오희균 ( Oh Hee-Kyun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
유선열 ( Ryu Sun-Youl ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
유민기 ( Yu Min-Gi ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
최근호 ( Choi Guen-Ho ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
장정록 ( Jang Jung-Rok ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
정승곤 ( Jung Seung-Gon ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
한만승 ( Han Man-Seung ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
KMID : 0360120090310060469
Abstract
Purpose: This study was performed to evaluate the effect of various graft materials used with a titanium cap on the ability of new bone formation in the rabbit calvarium.
Materials and Methods: A total of 32 sites of artificial bony defects were prepared on the calvaria of sixteen rabbits by using a trephine bur 8 mm in diameter. Each rabbit had two defect sites. 0.2 mm deep grooves were formed on the calvaria of sixteen rabbits by using a trephine bur 8 mm in diameter for the fixation of a titanium cap. The treatments were performed respectively as follows: without any graft for the control group (n=8), autogenous iliac bone graft for experimental group 1 (n=8), alloplastic bone graft (SynthoGraft(R), USA) for experimental group 2 (n=8), and xenogenic bone graft (NuOss(R), USA) for experimental group 3 (n=8). After the treatments, a titanium cap (8 mm in diameter, 4 mm high, and 0.2 mm thick) was fixed into the groove. At the third and sixth postoperative weeks, rabbits in each group were sacrificed for histological analysis.
Results: 1. In gross examination, the surgical sites showed no signs of inflammation or wound dehiscence, and semicircular-shaped bone remodeling was shown both in the experimental and control groups. 2. In histological analysis, the control group at the third week showed bone remodeling along the inner surface of the cap and at the contact region of the calvarium without any specific infiltration of inflammation tissue. Also, there was no soft tissue infiltration. Bone remodeling was observed around the grafted bone and along the inner surface of the titanium cap in experimental group 1, 2, and 3. 3. Histologically, all groups at the sixth week showed the increased area of bone remodeling and maturation compared to those at the third week. In experimental group 2, the grafted bone was partially absorbed by multi nucleated giant cells and new bone was formed by osteoblasts. In group 3, however, resorption of the grafted bone was not observed. 4. Autogenous bone at the third and sixth week showed the most powerful ability of new bone formation. The size of newly formed bone was in decreasing order by autogenous, alloplastic, and heterogenous bone graft. There was no statistically significant difference among autogenous, alloplastic, and heterogenous bones(p>0.05).
Summary: This result suggests that autogenous bone is the best choice for new bone formation, but when autogenous bone graft is in limited availability, alloplastic and xenogenic bone graft also can be an alternative bone graft material to use with a suitably guided membrane.
키워드
Titanium cap;Bone regeneration;Autogenous bone graft;Alloplastic bone graft;Xenogeneic bone graft
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